The Alcoholic Hepatitis Network project, AlcHepNet (http://www.alchepnet.org/), is sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). AlcHepNet aims to improve the treatment of alcohol-associated hepatitis, a leading cause of liver-related morbidity and mortality. The AlcHepNet consortium comprises six clinical study sites: Cleveland Clinic, Indiana University Clinical Center, Mayo Clinic Clinical Center, University of Louisville Clinical Center, UT Southwestern Medical Center, and Virginia Commonwealth University Clinical Center. The network is recruiting over 1,300 participants for clinical studies, following up with participants for 180 days, collecting more than 78,000 blood, urine, saliva, and liver biopsy bio-samples, capturing demographic and behavioral features, clinical conditions, laboratory tests, treatments, and outcomes, and generating multiomics data from microbiome, immunologic, proteomic, metabolomic, lipidomic, and RNA/ChIP-sequencing analyses. The Indiana University Data Coordinating Center (IU DCC) provides the essential research infrastructure, including experimental design, study implementation, data management, and statistical analysis, in support of the network's primary studies and the translational projects that utilize biospecimens collected through those studies. To facilitate effective research use of the rich and complex AlcHepNet data, the IU DCC has developed ARDaC, the Alcohol Research Data Commons, as the central data hub and research nexus (https://portal.ardac.org/). ... Read More

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